Jump to main content
Jump to site search

Issue 6, 2017
Previous Article Next Article

Synthesis of 3-((arylsulfonyl)methyl)indolin-2-ones via insertion of sulfur dioxide using anilines as the aryl source

Author affiliations

Abstract

Facile assembly of 3-((arylsulfonyl)methyl)indolin-2-ones via insertion of sulfur dioxide starting from anilines, N-arylacrylamides and DABCO·(SO2)2 is developed. This one-pot reaction proceeds efficiently in dichloroethane, leading to sulfonated oxindoles in good yields. Anilines serve as the aryl source, and the in situ generated sulfonyl radicals from sulfur dioxide as the key intermediates are trapped by N-arylacrylamides to provide the corresponding products. Additionally, a broad reaction scope is observed under mild conditions.

Graphical abstract: Synthesis of 3-((arylsulfonyl)methyl)indolin-2-ones via insertion of sulfur dioxide using anilines as the aryl source

Back to tab navigation

Supplementary files

Publication details

The article was received on 26 Jan 2017, accepted on 16 Feb 2017 and first published on 17 Feb 2017


Article type: Research Article
DOI: 10.1039/C7QO00075H
Citation: Org. Chem. Front., 2017,4, 1079-1083
  •   Request permissions

    Synthesis of 3-((arylsulfonyl)methyl)indolin-2-ones via insertion of sulfur dioxide using anilines as the aryl source

    T. Liu, D. Zheng and J. Wu, Org. Chem. Front., 2017, 4, 1079
    DOI: 10.1039/C7QO00075H

Search articles by author

Spotlight

Advertisements