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Cyclopropenes: a new tool for the study of biological systems

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Abstract

The development of novel bioorthogonal reagents for biological applications has increased considerably in the last decade. Of these tools, the modification of biological entities by metabolic labelling strategies employing chemical mini-tags has allowed the study of these entities within biological samples. Following this strategy, apart from azides, cyclopropene units have recently emerged as potential alternative mini-tags that react quickly in tetrazine and photoclick ligation reactions. Herein the most recent advances in bioorthogonal chemistry, covering the synthesis, stability and reactivity of cyclopropenes, as well its applications in biological systems, are reviewed.

Graphical abstract: Cyclopropenes: a new tool for the study of biological systems

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Publication details

The article was received on 19 Jan 2017, accepted on 12 Mar 2017 and first published on 16 Mar 2017


Article type: Review Article
DOI: 10.1039/C7QO00054E
Citation: Org. Chem. Front., 2017, Advance Article
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    Cyclopropenes: a new tool for the study of biological systems

    J. M. J. M. Ravasco, C. M. Monteiro and A. F. Trindade, Org. Chem. Front., 2017, Advance Article , DOI: 10.1039/C7QO00054E

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