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Synthesis and structure revision of symplocin A

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Abstract

Symplocin A, a linear peptide possessing N-terminal N,N-dimethylisoleucine, statine, and valic acid residues, has been synthesized for the first time employing our previously established ‘one-pot intramolecular tandem protocol’. Moreover, the stereochemistry of natural symplocin A was unambiguously revised through the confirmation by 1D NMR, 2D NMR, and HPLC comparisons with an authentic natural product.

Graphical abstract: Synthesis and structure revision of symplocin A

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Publication details

The article was received on 19 Jan 2017, accepted on 06 Feb 2017 and first published on 09 Feb 2017


Article type: Research Article
DOI: 10.1039/C7QO00052A
Citation: Org. Chem. Front., 2017, Advance Article
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    Synthesis and structure revision of symplocin A

    L. Shao, C. Si, Z. Mao, W. Zhou, T. F. Molinski, B. Wei and G. Lin, Org. Chem. Front., 2017, Advance Article , DOI: 10.1039/C7QO00052A

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