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Palladium-catalyzed β-selective C(sp2)–H carboxamidation of enamides by isocyanide insertion: synthesis of N-acyl enamine amides

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Abstract

An efficient synthesis of N-acyl enamine amides via palladium-catalyzed alkene C–H activation and isocyanide insertion has been developed. The reaction was realized with good regioselectivity through directing-group-assisted alkenyl C(sp2)–H bond carboxamidation under mild conditions. A facile pathway to β-amino amides was achieved via reduction of the synthesized N-acyl enamine amides.

Graphical abstract: Palladium-catalyzed β-selective C(sp2)–H carboxamidation of enamides by isocyanide insertion: synthesis of N-acyl enamine amides

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Publication details

The article was received on 19 Jan 2017, accepted on 25 Feb 2017, published on 27 Feb 2017 and first published online on 27 Feb 2017


Article type: Research Article
DOI: 10.1039/C7QO00049A
Citation: Org. Chem. Front., 2017, Advance Article
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    Palladium-catalyzed β-selective C(sp2)–H carboxamidation of enamides by isocyanide insertion: synthesis of N-acyl enamine amides

    Z. Xiong, D. Liang and S. Luo, Org. Chem. Front., 2017, Advance Article , DOI: 10.1039/C7QO00049A

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