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(1S)-(−)-N-Trifluoromethylthio-2,10-camphorsultam and its derivatives: easily available, optically pure reagents for asymmetric trifluoromethylthiolation

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Abstract

A family of easily scalable, shelf-stable, optically pure reagents (1S)-(−)-N-trifluoromethylthio-2,10-camphorsultam 1a–c was successfully developed. In particular, compound 1c was shown to be an efficient reagent that is capable of transferring chirality to other prochiral nucleophiles such as β-ketoesters, oxindoles and benzofuranones with good to excellent enantioselectivities.

Graphical abstract: (1S)-(−)-N-Trifluoromethylthio-2,10-camphorsultam and its derivatives: easily available, optically pure reagents for asymmetric trifluoromethylthiolation

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Publication details

The article was received on 16 Jan 2017, accepted on 09 Feb 2017, published on 10 Feb 2017 and first published online on 10 Feb 2017


Article type: Research Article
DOI: 10.1039/C7QO00042A
Citation: Org. Chem. Front., 2017, Advance Article
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    (1S)-(−)-N-Trifluoromethylthio-2,10-camphorsultam and its derivatives: easily available, optically pure reagents for asymmetric trifluoromethylthiolation

    H. Zhang, X. Leng, X. Wan and Q. Shen, Org. Chem. Front., 2017, Advance Article , DOI: 10.1039/C7QO00042A

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