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Issue 4, 2017
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Enantioselective conjugate addition of hydroxylamines to α,β-unsaturated 2-acyl imidazoles catalyzed by a chiral-at-metal Rh(III) complex

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Abstract

A catalytic enantioselective hydroxyamination of α,β-unsaturated 2-acyl imidazoles with N-protected hydroxyl amines catalyzed by a chiral-at-metal Rh(III) complex (0.5–2 mol%) has been developed. The approach affords valuable N-Boc protected β-amino acid derivatives in moderate to good yields with high enantioselectivity (up to 94% yield, 99.5% ee).

Graphical abstract: Enantioselective conjugate addition of hydroxylamines to α,β-unsaturated 2-acyl imidazoles catalyzed by a chiral-at-metal Rh(iii) complex

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Publication details

The article was received on 29 Dec 2016, accepted on 19 Jan 2017 and first published on 23 Jan 2017


Article type: Research Article
DOI: 10.1039/C6QO00865H
Citation: Org. Chem. Front., 2017,4, 573-577
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    Enantioselective conjugate addition of hydroxylamines to α,β-unsaturated 2-acyl imidazoles catalyzed by a chiral-at-metal Rh(III) complex

    T. Deng, G. K. Thota, Y. Li and Q. Kang, Org. Chem. Front., 2017, 4, 573
    DOI: 10.1039/C6QO00865H

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