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Issue 4, 2017
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Synthesis of tetrasubstituted symmetrical pyridines by iron-catalyzed cyclization of ketoxime acetates

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Abstract

An efficient iron-catalyzed cyclization of ketoxime acetates with N,N-dimethylaniline for the synthesis of symmetrical pyridines has been developed. A methyl carbon on N,N-dimethylaniline acts as a source of one carbon synthons. The reaction used readily available starting materials, tolerated various functional groups, and afforded 2,3,5,6-tetrasubstituted symmetrical pyridines in good yields.

Graphical abstract: Synthesis of tetrasubstituted symmetrical pyridines by iron-catalyzed cyclization of ketoxime acetates

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Publication details

The article was received on 13 Dec 2016, accepted on 22 Jan 2017, published on 23 Jan 2017 and first published online on 23 Jan 2017


Article type: Research Article
DOI: 10.1039/C6QO00809G
Citation: Org. Chem. Front., 2017,4, 597-602
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    Synthesis of tetrasubstituted symmetrical pyridines by iron-catalyzed cyclization of ketoxime acetates

    M. Zhao, L. Yu, N. Mo, Z. Ren, Y. Wang and Z. Guan, Org. Chem. Front., 2017, 4, 597
    DOI: 10.1039/C6QO00809G

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