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Issue 4, 2017
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Metal-free C5-selective halogenation of quinolines under aqueous conditions

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Abstract

An efficient and convenient method of C5-selective halogenation of quinoline derivatives was developed. The reaction proceeds smoothly in water with readily available N-halosuccinimides (NCS, NBS and NIS) as the halogenation reagents. This method features metal-free catalysis, no additional oxidants and additives, broad substrate scope and short reaction time.

Graphical abstract: Metal-free C5-selective halogenation of quinolines under aqueous conditions

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Publication details

The article was received on 29 Nov 2016, accepted on 28 Jan 2017 and first published on 07 Feb 2017


Article type: Research Article
DOI: 10.1039/C6QO00765A
Citation: Org. Chem. Front., 2017,4, 622-626
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    Metal-free C5-selective halogenation of quinolines under aqueous conditions

    J. Chen, T. Wang, Y. Liu, T. Wang, A. Lin, H. Yao and J. Xu, Org. Chem. Front., 2017, 4, 622
    DOI: 10.1039/C6QO00765A

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