Jump to main content
Jump to site search

Issue 6, 2017
Previous Article Next Article

Transition-metal-free direct perfluoroalkylation of quinoline amides at C5 position through radical cross-coupling under mild conditions

Author affiliations

Abstract

A simple and efficient method is established for the synthesis of perfluoroalkylated quinolines in the absence of any transition metal catalysts. The eco-friendly reaction reveals lower energy and time consumption. Desired products are isolated in good to excellent yields. A number of control experiments are carried out to illustrate that a radical cross-coupling process plays a vital role in the perfluoroalkylation.

Graphical abstract: Transition-metal-free direct perfluoroalkylation of quinoline amides at C5 position through radical cross-coupling under mild conditions

Back to tab navigation

Supplementary files

Publication details

The article was received on 24 Oct 2016, accepted on 21 Feb 2017 and first published on 22 Feb 2017


Article type: Research Article
DOI: 10.1039/C6QO00655H
Citation: Org. Chem. Front., 2017,4, 1116-1120
  •   Request permissions

    Transition-metal-free direct perfluoroalkylation of quinoline amides at C5 position through radical cross-coupling under mild conditions

    J. Xu, L. Qiao, B. Ying, X. Zhu, C. Shen and P. Zhang, Org. Chem. Front., 2017, 4, 1116
    DOI: 10.1039/C6QO00655H

Search articles by author

Spotlight

Advertisements