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Transition-metal-free direct perfluoroalkylation of quinoline amides at C5 position through radical cross-coupling under mild conditions

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Abstract

A simple and efficient method is established for the synthesis of perfluoroalkylated quinolines in the absence of any transition metal catalysts. The eco-friendly reaction reveals lower energy and time consumption. Desired products are isolated in good to excellent yields. A number of control experiments are carried out to illustrate that a radical cross-coupling process plays a vital role in the perfluoroalkylation.

Graphical abstract: Transition-metal-free direct perfluoroalkylation of quinoline amides at C5 position through radical cross-coupling under mild conditions

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Publication details

The article was received on 24 Oct 2016, accepted on 21 Feb 2017, published on 22 Feb 2017 and first published online on 22 Feb 2017


Article type: Research Article
DOI: 10.1039/C6QO00655H
Citation: Org. Chem. Front., 2017, Advance Article
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    Transition-metal-free direct perfluoroalkylation of quinoline amides at C5 position through radical cross-coupling under mild conditions

    J. Xu, L. Qiao, B. Ying, X. Zhu, C. Shen and P. Zhang, Org. Chem. Front., 2017, Advance Article , DOI: 10.1039/C6QO00655H

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