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Copper(I) and N-fluorobenzenesulfonimide-mediated direct regioselective halogenation of 8-amidoquinolines on the C5 position

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Abstract

An efficient and convenient method for the direct regioselective halogenation of 8-amidoquinolines has been developed. In the presence of CuX and N-fluorobenzenesulfonimide (NFSI), the C5-halogenation products of 8-acylaminoquinolines were obtained in moderate to excellent yields. This new procedure provides facile access to a variety of C5-halogenation of 8-amidoquinolines under mild conditions.

Graphical abstract: Copper(i) and N-fluorobenzenesulfonimide-mediated direct regioselective halogenation of 8-amidoquinolines on the C5 position

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Publication details

The article was received on 20 Oct 2016, accepted on 28 Jan 2017, published on 22 Feb 2017 and first published online on 22 Feb 2017


Article type: Research Article
DOI: 10.1039/C6QO00644B
Citation: Org. Chem. Front., 2017, Advance Article
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    Copper(I) and N-fluorobenzenesulfonimide-mediated direct regioselective halogenation of 8-amidoquinolines on the C5 position

    X. He, Y. Xu, L. Kong, H. Wu, D. Ji, Z. Wang, Y. Xu and Q. Zhu, Org. Chem. Front., 2017, Advance Article , DOI: 10.1039/C6QO00644B

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