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Issue 6, 2017
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Catalytic enantioselective bromohydroxylation of aryl olefins with flexible functionalities

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Abstract

A highly enantioselective bromohydroxylation of aryl olefins with flexible functionalities has been achieved with (DHQD)2PHAL as a catalyst and H2O as a nucleophile, giving a variety of optically active bromohydrins with up to 98% ee. An acid additive has been found to be beneficial for the reactivity and enantioselectivity.

Graphical abstract: Catalytic enantioselective bromohydroxylation of aryl olefins with flexible functionalities

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Publication details

The article was received on 18 Oct 2016, accepted on 21 Feb 2017 and first published on 22 Feb 2017


Article type: Research Article
DOI: 10.1039/C6QO00636A
Citation: Org. Chem. Front., 2017,4, 1084-1090
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    Catalytic enantioselective bromohydroxylation of aryl olefins with flexible functionalities

    J. Li, Z. Li, X. Zhang, B. Xu and Y. Shi, Org. Chem. Front., 2017, 4, 1084
    DOI: 10.1039/C6QO00636A

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