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Issue 3, 2017
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Aerobic oxidative decyanation–amidation of arylacetonitriles with urea as a nitrogen source

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Abstract

An iron-catalyzed aerobic oxidative amidation reaction of the inert C–CN bond of aryl acetonitriles to afford aryl amides has been developed. Urea is used as an efficient and convenient nitrogen source. This reaction provides practical access toward amide synthesis.

Graphical abstract: Aerobic oxidative decyanation–amidation of arylacetonitriles with urea as a nitrogen source

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Publication details

The article was received on 15 Oct 2016, accepted on 09 Dec 2016 and first published on 13 Dec 2016


Article type: Research Article
DOI: 10.1039/C6QO00635C
Citation: Org. Chem. Front., 2017,4, 331-334
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    Aerobic oxidative decyanation–amidation of arylacetonitriles with urea as a nitrogen source

    X. Xu, B. Li, Y. Zhao and Q. Song, Org. Chem. Front., 2017, 4, 331
    DOI: 10.1039/C6QO00635C

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