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Issue 2, 2017
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Aerobic copper catalyzed α-oxyacylation of ketones with carboxylic acids

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Abstract

A copper catalyzed direct α-oxyacylation of ketones with carboxylic acids has been developed. Various acids including aromatic and aliphatic acids are well tolerated, and the scope of ketones is also investigated. This protocol provides a convenient and benign method for the synthesis of α-acyloxycarbonyl compounds by using oxygen as the oxidant. In addition, we have investigated the role of copper and trapped the key intermediate to confirm the mechanism.

Graphical abstract: Aerobic copper catalyzed α-oxyacylation of ketones with carboxylic acids

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Publication details

The article was received on 23 Sep 2016, accepted on 14 Nov 2016 and first published on 16 Nov 2016


Article type: Research Article
DOI: 10.1039/C6QO00575F
Citation: Org. Chem. Front., 2017,4, 163-169
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    Aerobic copper catalyzed α-oxyacylation of ketones with carboxylic acids

    X. Huang, X. Liang, J. Yuan, Z. Ni, Y. Zhou and Y. Pan, Org. Chem. Front., 2017, 4, 163
    DOI: 10.1039/C6QO00575F

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