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Issue 4, 2017
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AgNO3-catalyzed direct C–H arylation of quinolines by oxidative decarboxylation of aromatic carboxylic acids

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Abstract

An efficient silver-catalyzed intermolecular decarboxylative arylation of quinolines has been developed using cheap aromatic carboxylic acids as arylating reagents under microwave irradiation. The reaction demonstrates a broad substrate scope and excellent functional group tolerance. This method provided an effective and easy way to synthesize arylated quinoline derivatives. The radical trapping experiments showed that this process involved the radical mechanism.

Graphical abstract: AgNO3-catalyzed direct C–H arylation of quinolines by oxidative decarboxylation of aromatic carboxylic acids

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Publication details

The article was received on 11 Sep 2016, accepted on 02 Dec 2016, published on 05 Dec 2016 and first published online on 05 Dec 2016


Article type: Research Article
DOI: 10.1039/C6QO00533K
Citation: Org. Chem. Front., 2017,4, 545-554
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    AgNO3-catalyzed direct C–H arylation of quinolines by oxidative decarboxylation of aromatic carboxylic acids

    J. Yuan, L. Yang, P. Mao and L. Qu, Org. Chem. Front., 2017, 4, 545
    DOI: 10.1039/C6QO00533K

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