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Issue 6, 2017
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Oxidative annulations triggered by a simple Lewis acid: facile synthesis of benzofurans

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Abstract

The first example of Lewis acid promoted efficient one-pot synthesis of benzofurans is presented. Unlike previous reports on oxidative annulations between phenols and internal acetylenes, a simple and highly facile Lewis acid mediated protocol is presented. The Lewis acid (ZnCl2) played a crucial role to promote dual (C–H and O–H) bond formation, presumably via a six-membered cyclic transition state. Significantly, a variety of benzofurans were accomplished with symmetrical/unsymmetrical acetylenes.

Graphical abstract: Oxidative annulations triggered by a simple Lewis acid: facile synthesis of benzofurans

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Publication details

The article was received on 10 Sep 2016, accepted on 29 Jan 2017 and first published on 08 Feb 2017


Article type: Research Article
DOI: 10.1039/C6QO00531D
Citation: Org. Chem. Front., 2017,4, 972-977
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    Oxidative annulations triggered by a simple Lewis acid: facile synthesis of benzofurans

    C. Sreenivasulu, A. Gopi Krishna Reddy and G. Satyanarayana, Org. Chem. Front., 2017, 4, 972
    DOI: 10.1039/C6QO00531D

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