Issue 1, 2017

A novel spirocyclic triterpenoid and a new taraxerane triterpenoid from Teucrium viscidum

Abstract

Two new triterpenoids, teuviscins A (1) and B (2), were isolated from the whole plants of Teucrium viscidum. Compound 1 possessed a rare 7(8→9)abeo-9R-D:C-friedo-B′:A′-neo-gammacerane skeleton, and compound 2 is a taraxerane triterpene acid. Their structures were characterized by extensive spectroscopic methods (HR-ESI-MS, 1D and 2D NMR), and the absolute configurations of 1 and 2 were secured by single-crystal X-ray diffraction analyses using Cu Kα radiation. Compound 2 showed anti-AD bioactivity which delayed animals paralysis of transgenic AD Caenorhabditis elegans.

Graphical abstract: A novel spirocyclic triterpenoid and a new taraxerane triterpenoid from Teucrium viscidum

Supplementary files

Article information

Article type
Research Article
Submitted
15 Aug 2016
Accepted
09 Oct 2016
First published
10 Oct 2016

Org. Chem. Front., 2017,4, 42-46

A novel spirocyclic triterpenoid and a new taraxerane triterpenoid from Teucrium viscidum

Z. Li, F. Qi, D. Zhi, Q. Hu, Y. Liu, Z. Zhang and D. Fei, Org. Chem. Front., 2017, 4, 42 DOI: 10.1039/C6QO00460A

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