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pH-sensitive multifunctional fluorescent probe based on N-annulated perylene for the sensitive and selective detection of hypochlorous acid

Abstract

Hypochlorous acid (HOCl) is a representative reactive oxygen species (ROS), which plays important roles in signaling and homeostasis. And it is also an important cobleaching agent and disinfectant in industry and life. Therefore, it is of significant importance to detect HOCl accurately for the diagnosis or treatment of various diseases and the protection of the environment. Considering the excellent photophysical properties, N-annulated perylene (NP) was chosen as the fluorophore to design the multifunctional fluorescent probe (PNPM) for the sensitive and selective detection of HOCl for the first time. Benefiting from the introduction of piperazine moiety, the probe became pH-sensitive due to the photo-induced electron transfer (PET) process. In the neutral environment, PNPM was a turn-on probe towards HOCl with the limit of detection of 31.7 nM. However, PNPM became a ratiometric fluorescent under the weak acidic conditions with a better limit of detection (15.3 nM). This amazing property made the probe possess the ability to detect pH and HOCl at the same time. Therefore, PNPM was successfully employed to detect HOCl in fetal bovine serum and different water samples, where they could also monitor the pH values of the solution, showing its huge potentials in practical applications.

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Publication details

The article was received on 03 Jul 2017, accepted on 05 Aug 2017 and first published on 08 Aug 2017


Article type: Research Article
DOI: 10.1039/C7QM00298J
Citation: Mater. Chem. Front., 2017, Accepted Manuscript
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    pH-sensitive multifunctional fluorescent probe based on N-annulated perylene for the sensitive and selective detection of hypochlorous acid

    J. Hua, X. Zhang, Y. Yan, Q. Peng, J. Wang and Y. Hang, Mater. Chem. Front., 2017, Accepted Manuscript , DOI: 10.1039/C7QM00298J

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