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Direct Correlation of PNIPAM Thermal Transition on Magnetic Resonance Relaxation of Iron Oxide Nanoparticles

Abstract

Poly(N-isopropylacrylamide) (PNIPAM) which undergoes temperature dependent transition from hydrophilic to hydrophobic has played a crucial role in the development of stimuli-responsive multifunctional nanoparticles. In particular, iron oxide nanoparticles coated with PNIPAM has been effectively developed to enable stimuli responsive drug delivery and imaging agents. However, the PNIPAM transition from hydrophilic to hydrophobic at physiologically relevant tempertures renders colloidal nanoparticles unstable resulting in aggregation and precipitation from solution. Consequently, a direct correlative anlaysis of the thermally induced phase transition of PNIPAM on magnetic resonance properties of nanoparticles has been not been possible as the changes in proton relaxivity have been dominated by the colloidal agglomeration of nanoparticles. Herein, we report a colloidally stable thermoresponsive PNIPAM-grafted-PGMA coated magnetite core/shell nanoparticles (PNIPAM-PGMA-NPs) that enables a direct analysis of PNIPAM phase changes in solution on the overal magnetic resonance relaxivity of nanoparticles in suspension.

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Publication details

The article was received on 06 May 2017, accepted on 20 Jul 2017 and first published on 01 Aug 2017


Article type: Research Article
DOI: 10.1039/C7QM00202E
Citation: Mater. Chem. Front., 2017, Accepted Manuscript
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    Direct Correlation of PNIPAM Thermal Transition on Magnetic Resonance Relaxation of Iron Oxide Nanoparticles

    N. Izza Taib, V. Agarwal, N. M. Smith, R. Woodward, T. G. St Pierre and S. Iyer, Mater. Chem. Front., 2017, Accepted Manuscript , DOI: 10.1039/C7QM00202E

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