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Supramolecular conjugated polymer materials for organelle imaging in living cells

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Abstract

A novel supramolecular system based on conjugated polymers was developed to realize specific targeting and imaging of organelles in living cells. The carboxyl group-modified polythiophene derivative (PT) forms a complex with six histidine equipped Tat peptide via Ni2+ ion chelation, hydrogen bonds and electrostatic interactions (PT/Ni2+/Tat-His6). The complex can reassemble with RFP-His10 due to the relatively high affinity of Ni2+ towards His10-tag compared to His6-tag. Thus, the PT/Ni2+/Tat-His6 complex could selectively label and image organelles expressing His10-tag in living cells with high stability.

Graphical abstract: Supramolecular conjugated polymer materials for organelle imaging in living cells

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Publication details

The article was received on 17 Mar 2017, accepted on 14 Apr 2017 and first published on 17 Apr 2017


Article type: Research Article
DOI: 10.1039/C7QM00105C
Citation: Mater. Chem. Front., 2017, Advance Article
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    Supramolecular conjugated polymer materials for organelle imaging in living cells

    R. Hu, S. Li, H. Lu, L. Liu, F. Lv and S. Wang, Mater. Chem. Front., 2017, Advance Article , DOI: 10.1039/C7QM00105C

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