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Aggregation-induced emission nanoparticles as photosensitizer for two-photon photodynamic therapy

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Abstract

Two-photon excited fluorescence microscopy and nanoparticle-assisted photodynamic therapy (PDT) are two important areas in biomedical research, and their combination can be more beneficial. A type of red emissive photosensitizer (PS) with aggregation-induced emission (AIE) features, which is called tetraphenylethylene (TPE-red), was synthesized and further encapsulated with poly(styrene-co-maleic anhydride) (PSMA) to form nanoparticles. Two-photon fluorescence, as well as two-photon excited reactive oxygen species (ROS) generation by TPE-red–PSMA nanoparticles, was characterized. A large two-photon absorption cross-section was observed at 1040 nm with a femtosecond (fs) laser. PDT via two-photon excitation was well realized on tumor cells, using TPE-red–PSMA nanoparticles as PSs under 1040 nm fs laser excitation. Based on our study, we believe that two-photon excited PDT with AIE-active PSs has great potential applications in deep tissue imaging-guided therapy.

Graphical abstract: Aggregation-induced emission nanoparticles as photosensitizer for two-photon photodynamic therapy

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Publication details

The article was received on 27 Feb 2017, accepted on 23 Jun 2017 and first published on 26 Jun 2017


Article type: Research Article
DOI: 10.1039/C7QM00092H
Citation: Mater. Chem. Front., 2017, Advance Article
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    Aggregation-induced emission nanoparticles as photosensitizer for two-photon photodynamic therapy

    N. Alifu, X. Dong, D. Li, X. Sun, A. Zebibula, D. Zhang, G. Zhang and J. Qian, Mater. Chem. Front., 2017, Advance Article , DOI: 10.1039/C7QM00092H

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