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All-organic luminescent nanodots from corannulene and cyclodextrin nano-assembly: continuous-flow synthesis, non-linear optical properties, and bio-imaging applications

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Abstract

Control of structure and function, at the nanometer scale, remains a formidable challenge in the arena of self-assembled soft materials. Here, we report on the design of a small molecule-based two-component assembly system in which the assembly partners can recognize each other through host–guest interactions. One component is hydrophobic and carries a donor–acceptor type of electronic structure. This is realized by employing a bucky-bowl corannulene derivative. The other component is hydrophilic and hollow. This is achieved by using γ-cyclodextrin, the largest and least studied member of the cyclic oligosaccharide family. In a chemically polar aqueous environment, the two partners come together to form an amphiphilic structure that assembles further into nanosized, quasicrystalline, dot-like, non-toxic, all-organic structures showing two-photon activity and bright green luminescence in water upon excitation at 800 nm. The devised synthesis is achieved by a simple mixing process carried out under continuous-flow conditions. Therefore, in a scalable manner, a constant supply of the assembly components results in continuous fabrication of the nanostructures. Non-linear optical activity and biocompatibility aspects suggest utility of the prepared new class of soft organic nano-dots as contrast agents or labeling tags for visualizing biological specimens. This aspect is examined and demonstrated through two-photon fluorescence imaging of cancer cell lines.

Graphical abstract: All-organic luminescent nanodots from corannulene and cyclodextrin nano-assembly: continuous-flow synthesis, non-linear optical properties, and bio-imaging applications

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Publication details

The article was received on 11 Feb 2017, accepted on 04 Apr 2017 and first published on 20 Apr 2017


Article type: Research Article
DOI: 10.1039/C7QM00063D
Citation: Mater. Chem. Front., 2017, Advance Article
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    All-organic luminescent nanodots from corannulene and cyclodextrin nano-assembly: continuous-flow synthesis, non-linear optical properties, and bio-imaging applications

    S. Sreejith, N. V. Menon, Y. Wang, H. Joshi, S. Liu, K. C. Chong, Y. Kang, H. Sun and M. C. Stuparu, Mater. Chem. Front., 2017, Advance Article , DOI: 10.1039/C7QM00063D

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