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Hybrid polymeric nanoprobes for folate receptor-targeted photoacoustic imaging in vivo

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Abstract

To construct biocompatible imaging nanoprobes and apply them to receptor-specific targeting of breast cancers is of great significance for precise diagnosis and personalized therapy serving nanomedicine. Herein, hybrid polymeric methylene blue-embedded nanoprobes (PBCA-MB@CS-FA) for folate receptor-targeted photoacoustic (PA) imaging have been successfully fabricated. Phantom imaging and in vitro cell experiments confirmed their apparent contrast enhancement and strong binding affinity. The administration into MDA-MB231 tumor-xenografted nude mice showed 10-fold higher intensity of PA signals compared to that of non-targeted control. These features make them promising PA nanoprobes for non-invasive molecular diagnosis, and more importantly for potential PA image-guided surgery/therapy against breast cancers in the early stage.

Graphical abstract: Hybrid polymeric nanoprobes for folate receptor-targeted photoacoustic imaging in vivo

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Publication details

The article was received on 20 Sep 2016, accepted on 18 Nov 2016 and first published on 07 Dec 2016


Article type: Research Article
DOI: 10.1039/C6QM00227G
Citation: Mater. Chem. Front., 2017, Advance Article
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    Hybrid polymeric nanoprobes for folate receptor-targeted photoacoustic imaging in vivo

    Y. Li, Y. Song, W. Chen, Q. Xu and Z. Liu, Mater. Chem. Front., 2017, Advance Article , DOI: 10.1039/C6QM00227G

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