Jump to main content
Jump to site search

Issue 5, 2017
Previous Article Next Article

Hybrid polymeric nanoprobes for folate receptor-targeted photoacoustic imaging in vivo

Author affiliations

Abstract

To construct biocompatible imaging nanoprobes and apply them to receptor-specific targeting of breast cancers is of great significance for precise diagnosis and personalized therapy serving nanomedicine. Herein, hybrid polymeric methylene blue-embedded nanoprobes (PBCA-MB@CS-FA) for folate receptor-targeted photoacoustic (PA) imaging have been successfully fabricated. Phantom imaging and in vitro cell experiments confirmed their apparent contrast enhancement and strong binding affinity. The administration into MDA-MB231 tumor-xenografted nude mice showed 10-fold higher intensity of PA signals compared to that of non-targeted control. These features make them promising PA nanoprobes for non-invasive molecular diagnosis, and more importantly for potential PA image-guided surgery/therapy against breast cancers in the early stage.

Graphical abstract: Hybrid polymeric nanoprobes for folate receptor-targeted photoacoustic imaging in vivo

Back to tab navigation

Supplementary files

Publication details

The article was received on 20 Sep 2016, accepted on 18 Nov 2016 and first published on 07 Dec 2016


Article type: Research Article
DOI: 10.1039/C6QM00227G
Citation: Mater. Chem. Front., 2017,1, 916-921
  •   Request permissions

    Hybrid polymeric nanoprobes for folate receptor-targeted photoacoustic imaging in vivo

    Y. Li, Y. Song, W. Chen, Q. Xu and Z. Liu, Mater. Chem. Front., 2017, 1, 916
    DOI: 10.1039/C6QM00227G

Search articles by author

Spotlight

Advertisements