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Issue 1, 2017
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A luminescence switch-on assay for the detection of specific gene deletion using G-quadruplex DNA and silver nanoclusters

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Abstract

A switch-on gene deletion detection platform is reported based on the alteration of the effective distance between G-quadruplex DNA and silver nanoclusters (AgNCs). Moreover, the role of the G-quadruplex structure in interacting with AgNCs has also been demonstrated. The detection of the deletion mutants of LMP1 and CCR5 genes is performed as the proof-of-concept of our assay. Finally, the potential biological application of the assay was demonstrated in 10% v/v human serum.

Graphical abstract: A luminescence switch-on assay for the detection of specific gene deletion using G-quadruplex DNA and silver nanoclusters

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Publication details

The article was received on 26 May 2016, accepted on 02 Aug 2016 and first published on 17 Aug 2016


Article type: Research Article
DOI: 10.1039/C6QM00068A
Citation: Mater. Chem. Front., 2017,1, 128-131
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    A luminescence switch-on assay for the detection of specific gene deletion using G-quadruplex DNA and silver nanoclusters

    M. Wang, W. Wang, C. Liu, J. Liu, T. Kang, C. Leung and D. Ma, Mater. Chem. Front., 2017, 1, 128
    DOI: 10.1039/C6QM00068A

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