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Issue 1, 2017
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Self-healing alginate–gelatin biohydrogels based on dynamic covalent chemistry: elucidation of key parameters

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Abstract

In this work, gelatin was crosslinked with oxidized alginate in the presence of borax yielding a hybrid biohydrogel system with the ability to self-repair upon mechanical damage. A judicious balance between concentration, stoichiometric ratio of the two biopolymers and gelatin source was found necessary to achieve optimal self-healing properties of these biohydrogels. The pH was found to have a major influence on the reconstruction of the damaged hydrogel interface, confirming that the dynamic Schiff base linkages between the amine groups of gelatin and the aldehyde groups of oxidized alginate play a fundamental role on the healing process of the hybrid gels.

Graphical abstract: Self-healing alginate–gelatin biohydrogels based on dynamic covalent chemistry: elucidation of key parameters

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Publication details

The article was received on 25 May 2016, accepted on 15 Jun 2016 and first published on 29 Jul 2016


Article type: Research Article
DOI: 10.1039/C6QM00066E
Citation: Mater. Chem. Front., 2017,1, 73-79
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    Self-healing alginate–gelatin biohydrogels based on dynamic covalent chemistry: elucidation of key parameters

    A. Pettignano, M. Häring, L. Bernardi, N. Tanchoux, F. Quignard and D. Díaz Díaz, Mater. Chem. Front., 2017, 1, 73
    DOI: 10.1039/C6QM00066E

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