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Issue 2, 2017
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Thermo-sensitive poly(VCL-4VP-NVP) ionic microgels: synthesis, cytotoxicity, hemocompatibility, and sustained release of anti-inflammatory drugs

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Abstract

Thermosensitive poly(VCL-4VP-NVP) ionic microgels were prepared by in situ quaternization crosslinking reaction during surfactant free emulsion polymerization (SFEP) with N-vinylcaprolactam (VCL) as the main monomer, 4-vinylpyridine (4VP) as the quaternizable co-monomer, N-vinyl-2-pyrrolidone (NVP) as the second co-monomer and 1,6-dibromohexane (6Br) as the quaternization crosslinker. The obtained ionic microgels were spherical in shape with a narrow size distribution and exhibited thermo-sensitive behavior. These ionic microgels showed low cytotoxicity at concentrations lower than 25 µg mL−1, excellent hemocompatibility at concentrations up to 1000 µg mL−1, and could be up taken into the cytoplasm regime of HEK-293 cells without entering the nucleus. It was found that these ionic microgels were suitable for the loading and sustained release of a nonsteroidal anti-inflammatory drug, diclofenac sodium (DS). The drug loading content (DLC) of DS in the microgels could reach ca. 12% with an encapsulation efficiency (EE) of up to 68%. Furthermore, 60% loaded DS could be sustainably released at 37 °C from the drug-loaded microgels within 400 min following a first-order exponential kinetics.

Graphical abstract: Thermo-sensitive poly(VCL-4VP-NVP) ionic microgels: synthesis, cytotoxicity, hemocompatibility, and sustained release of anti-inflammatory drugs

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Publication details

The article was received on 08 May 2016, accepted on 25 Jun 2016 and first published on 15 Aug 2016


Article type: Research Article
DOI: 10.1039/C6QM00046K
Citation: Mater. Chem. Front., 2017,1, 369-379
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    Thermo-sensitive poly(VCL-4VP-NVP) ionic microgels: synthesis, cytotoxicity, hemocompatibility, and sustained release of anti-inflammatory drugs

    X. Zhou, Q. Yang, J. Li, J. Nie, G. Tang and B. Du, Mater. Chem. Front., 2017, 1, 369
    DOI: 10.1039/C6QM00046K

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