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Issue 3, 2018
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Synthesis and structure of new binuclear ruthenium(II) arene benzil bis(benzoylhydrazone) complexes: investigation on antiproliferative activity and apoptosis induction

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Abstract

A series of binuclear ruthenium(II) arene benzil bis(benzoylhydrazone) complexes (1–6) of the common composition [(η6-arene)2Ru2(L)Cl2] (arene = benzene or p-cymene; L = benzil bis(benzoylhydrazone derivatives)) have been synthesized. The synthesised complexes have been thoroughly characterised by elemental analysis, IR, NMR, UV-vis and ESI-MS spectral methods. The coordination of the binucleating ligand to each ruthenium centre through azomethine nitrogen and imidolate oxygen was confirmed by single crystal XRD, which indicates the presence of the pseudo octahedral geometry. All the complexes were carefully screened for their cytotoxicity against HeLa, MDA-MB-231 and Hep G2 cells under in vitro conditions. Interestingly, the complexes 4 and 6 exhibit higher cytotoxicity than cisplatin, with low IC50 values against all screened cancer cell lines. Furthermore, the mode of cell death in MDA-MB-231 cells was assessed by AO-EB, Hoechst 33258 staining and a flow cytometry technique along with the comet assay. The result of western blot analysis suggests that complexes 4 and 6 were shown to induce apoptosis via the mitochondrial pathway by up-regulating p53 and Bax, and down-regulating Bcl-2.

Graphical abstract: Synthesis and structure of new binuclear ruthenium(ii) arene benzil bis(benzoylhydrazone) complexes: investigation on antiproliferative activity and apoptosis induction

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Publication details

The article was received on 01 Dec 2017, accepted on 24 Dec 2017 and first published on 26 Dec 2017


Article type: Research Article
DOI: 10.1039/C7QI00761B
Citation: Inorg. Chem. Front., 2018,5, 585-596
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    Synthesis and structure of new binuclear ruthenium(II) arene benzil bis(benzoylhydrazone) complexes: investigation on antiproliferative activity and apoptosis induction

    M. S. Mohamed Kasim, S. Sundar and R. Rengan, Inorg. Chem. Front., 2018, 5, 585
    DOI: 10.1039/C7QI00761B

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