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Photo-induced DNA cleavage by zinc-substituted myoglobin with a redesigned active center

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Abstract

Myoglobin with a redesigned active center was constructed and reconstituted with zinc protoporphyrin (ZnPP), which was shown to exhibit novel photo-induced DNA cleavage activities, involving a hydroxyl radical (˙OH) with a minor contribution from singlet oxygen (1O2), as confirmed by spin-trapping studies for the first time.

Graphical abstract: Photo-induced DNA cleavage by zinc-substituted myoglobin with a redesigned active center

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Publication details

The article was received on 05 Jul 2017, accepted on 09 Oct 2017 and first published on 11 Oct 2017


Article type: Research Article
DOI: 10.1039/C7QI00384F
Citation: Inorg. Chem. Front., 2017, Advance Article
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    Photo-induced DNA cleavage by zinc-substituted myoglobin with a redesigned active center

    Z. Shi, K. Du, B. He, S. Gao, G. Wen and Y. Lin, Inorg. Chem. Front., 2017, Advance Article , DOI: 10.1039/C7QI00384F

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