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Carbon Based Drug Delivery System Derived from One-Dimensional Coordination Polymer, Doxorubicin Loading and Redox-Responsive Release

Abstract

Since controlled release of drug molecules under external stimuli is an essential strategy for effective tumor therapy, herein a redox-responsive drug delivery system (Ag-SS-MC) had been fabricated successfully through the modification of disulfide bonds on coordination polymer derived mesoporous carbon nanoparticle (MC) with nanoscale Ag as the “cap”. In this drug delivery system, the Ag “caps” are fastened on disulfide linker tightly, which blocks the pores of MC and impedes unexpected leakage of loaded doxorubicin (DOX). This drug delivery system exhibits striking DOX loading property, with loading ratio as high as 20.6 %. Ag-SS-MC keeps stable under normal physiologic condition, but the loaded DOX begin releasing in the presence of reducing agent, glutathione (GSH), which is caused by reductive broken of disulfide bonds. MTT assays exhibit, after incubation with human cervical cancer cell line (HeLa) for 24 h, the cytotoxicity of blank Ag-SS-MC carrier can almost be ignored. On the contrary, under the same condition, DOX loaded drug carrier system possesses high antitumor activity. Ag-SS-MC exhibits superior drug loading, high extracellular stability, redox-responsive intracellular drug release and excellent biocompatibility, all these characters make it a promising drug delivery system for tumor therapy.

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Publication details

The article was received on 09 May 2017, accepted on 08 Jun 2017 and first published on 13 Jun 2017


Article type:
DOI: 10.1039/C7QI00251C
Citation: Inorg. Chem. Front., 2017, Accepted Manuscript
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    Carbon Based Drug Delivery System Derived from One-Dimensional Coordination Polymer, Doxorubicin Loading and Redox-Responsive Release

    Y. Jia, X. Xu, J. Ou, X. Liu and F. Shi, Inorg. Chem. Front., 2017, Accepted Manuscript , DOI: 10.1039/C7QI00251C

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