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In-situ luminescence analysis: a new light on monitoring calcium phosphate phase transitions

Abstract

In this work, in-situ luminescence analysis was applied for the first time for monitoring the phase transitions on calcium phosphate (CaP) and confirmed by synchrotron in-situ X-ray diffraction in addition to in-situ infrared spectroscopy, with simultaneous measurements of pH and ion conductivity. Applying doped Ce3+ and Eu3+ as local coordination sensors, the high sensitivity of their emission spectra upon the changes in the coordination sphere of the doped cations sites enabled to detect the formation of amorphous calcium phosphate (ACP) and Ca5(PO4)3OH, besides their posterior transitions to CaHPO4∙2H2O and Ca8H2(PO4)6∙5H2O under real reaction conditions. Calcium phosphates are widely present in mammal organisms and understanding their phase transitions is important to comprehend the conversion between healthy and diseased tissues. In-situ luminescence measurements are advantageous for allowing monitoring these phase transitions in a fast and sensitive fashion also in conventional laboratories, independent from synchrotron radiation.

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Publication details

The article was received on 29 Mar 2017, accepted on 04 May 2017 and first published on 05 May 2017


Article type:
DOI: 10.1039/C7QI00172J
Citation: Inorg. Chem. Front., 2017, Accepted Manuscript
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    In-situ luminescence analysis: a new light on monitoring calcium phosphate phase transitions

    H. Terraschke, M. Rothe, A. Tsirigoni, P. Lindenberg, L. Ruiz Arana, N. Heidenreich, F. Bertram and M. Etter, Inorg. Chem. Front., 2017, Accepted Manuscript , DOI: 10.1039/C7QI00172J

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