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Mannose conjugated multi-layered polymeric nano carrier system for controlled and targeted release on alveolar macrophages

Abstract

To improve the performance of drug delivery system in the macrophages, targeting ligand conjugated polymeric carriers have been realized to be a vital role for targeted, sustainable and controlled drug release with remarkable biocompatibility and bioavailability. The primary goal of this present study was to fabricate a multilayered polymeric nanocarrier system with targeting moiety with releasing of multi-drugs (rifampicin and isoniazid) for pulmonary tuberculosis. In this regard, sodium alginate grafted allylamine-rifampicin and chitosan grafted allylamine-mannose was established as nano-sized materials by simple and facile method. A series of physio-chemical characterization like FTIR, XRD, SEM, TEM and AFM were applied to characterize and confirm the structure and shape of the nanocarrier. From the in-vitro drug release studies, releasing patterns of rifampicin and isoniazid in response to the lysozyme environment were observed. Biological evaluations of the prepared nano polymeric system have been investigated by cell cytotoxicity, cellular uptake and intra-cellular protein leakage, and which confirms that future clinical applications of these materials in the tuberculosis field are feasible.

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Publication details

The article was accepted on 01 Dec 2017 and first published on 04 Dec 2017


Article type: Paper
DOI: 10.1039/C7PY02000G
Citation: Polym. Chem., 2017, Accepted Manuscript
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    Mannose conjugated multi-layered polymeric nano carrier system for controlled and targeted release on alveolar macrophages

    R. A. Praphakaran, H. Shakila, A. D. V. N., M. A. Munusamy, S. S. Kumar and M. Rajan, Polym. Chem., 2017, Accepted Manuscript , DOI: 10.1039/C7PY02000G

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