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Synthesis and bioconjugation of first alkynylated poly(dithieno[3,2-b:2′,3′-d]pyrrole)s

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Abstract

First synthesis of an alkynylated dithieno[3,2-b:2′,3′-d]pyrrole (DTP) monomer was developed, which allows electrochemical polymerization on platinum and indium tin oxide (ITO) electrodes. The obtained DTP-based polymer (pDTP) was successfully post-modified with redox active and biological entities via bio-orthogonal 1,3-dipolar cycloaddition reactions and [2 + 2]-cycloaddition. In vitro experiments with A549-human lung carcinoma cells evidenced the general biocompatibility of the compositionally tuneable pDTP-coated electrodes.

Graphical abstract: Synthesis and bioconjugation of first alkynylated poly(dithieno[3,2-b:2′,3′-d]pyrrole)s

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Publication details

The article was received on 06 Sep 2017, accepted on 05 Nov 2017 and first published on 06 Nov 2017


Article type: Communication
DOI: 10.1039/C7PY01528C
Citation: Polym. Chem., 2017, Advance Article
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    Synthesis and bioconjugation of first alkynylated poly(dithieno[3,2-b:2′,3′-d]pyrrole)s

    S. Schmid, J. Gačanin, Y. Wu, T. Weil and P. Bäuerle, Polym. Chem., 2017, Advance Article , DOI: 10.1039/C7PY01528C

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