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Multifunctional polyphosphazene-coated multi-walled carbon nanotubes for the synergistic treatment of redox-responsive chemotherapy and effective photothermal therapy

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Abstract

It is a long-pursued goal to improve the antitumor efficiency while decreasing the systemic side effects of therapeutic agents of cancers. In this study, a multifunctional drug delivery system (DDS) for chemo-photothermal therapeutics was developed by coating an anticancer-drug-containing polyphosphazene (PPZ) onto multi-walled carbon nanotubes (MWNTs) via one-pot in situ polymerization of doxorubicin (DOX) and bis-(4-hydroxyphenyl)-disulfide (HPS) with hexachlorocyclotriphosphazene. The DOX loading ratio and release rate were precisely tuned via the adjustment of the DOX to HPS molar ratio. MWNTs were used as a nanotemplate and near-infrared photothermal conversion agent for effective photothermal therapy. Remarkably, this multifunctional DDS selectively suppressed and killed cancer cells, but negligibly affected normal cells. Hence, this DDS demonstrates the proof-of-concept for effective chemo-photothermal synergistic therapy.

Graphical abstract: Multifunctional polyphosphazene-coated multi-walled carbon nanotubes for the synergistic treatment of redox-responsive chemotherapy and effective photothermal therapy

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Publication details

The article was received on 01 Sep 2017, accepted on 01 Oct 2017 and first published on 03 Oct 2017


Article type: Communication
DOI: 10.1039/C7PY01485F
Citation: Polym. Chem., 2017, Advance Article
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    Multifunctional polyphosphazene-coated multi-walled carbon nanotubes for the synergistic treatment of redox-responsive chemotherapy and effective photothermal therapy

    D. Wang, Y. Ren, Y. Shao and L. Meng, Polym. Chem., 2017, Advance Article , DOI: 10.1039/C7PY01485F

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