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An efficient approach to synthesize glycerol dendrimers via thiol-yne “click” chemistry and their application in stabilization of gold nanoparticles with X-ray attenuation property

Abstract

We report here a facile, robust and efficient synthetic approach to glycerol dendrimers in different generations with up to 256 terminal groups, by using light-mediated thiol-yne “click” reaction and propargylation in an iterative fashion. Neither transition metal nor heating are required during the syntheses. The synthesized first (G1), second (G2) and third (G3) generation dendrimers are well soluble in water and are demonstrated to be nontoxic to HeLa cell. These dendrimers are good organic nanotemplates in stabilization of gold nanoparticles (AuNPs) in aqueous solution, and a series of narrowly-dispersed AuNPs (d = 1.2 - 8 nm) were prepared. These AuNPs with good stability exhibit X-ray attenuation property thus could be potentially used as computed tomography (CT) contrast agents. In this study, the developed glycerol dendrimers with alkyne or hydroxyl termini would be good platform for the construction of muntifunctional theranostic nanoagents for targeted drug delivery and imaging of diseases.

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Publication details

The article was received on 25 Aug 2017, accepted on 07 Oct 2017 and first published on 09 Oct 2017


Article type: Paper
DOI: 10.1039/C7PY01436H
Citation: Polym. Chem., 2017, Accepted Manuscript
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    An efficient approach to synthesize glycerol dendrimers via thiol-yne “click” chemistry and their application in stabilization of gold nanoparticles with X-ray attenuation property

    N. Li, T. H. Tsoi, W. Lo, Y. Gu, H. Wan and W. Wong, Polym. Chem., 2017, Accepted Manuscript , DOI: 10.1039/C7PY01436H

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