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Issue 45, 2017
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One-pot preparation of polylactic acid-ibuprofen conjugates and their performance characterization

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Abstract

A series of polylactic acid-ibuprofen (PLA-IBU) conjugates was directly synthesized via melt polycondensation of lactic acid (LA) with ibuprofen (IBU) in the presence of 0.3 wt% SnO at 160 °C for 6 h. The structures of the PLA-IBU conjugates were confirmed by FTIR and 1H NMR. According to the GPC and DSC results, the molecular weight and Tg of the PLA-IBUs with different feed ratios increase as the feed amount of LA increases. The drug content of these IBU-conjugated biodegradable polymers can also be simply controlled by adjusting the monomer feed ratio to reach the expected levels. The preliminary biological tests show that the PLA-IBU conjugates have the anticipated pharmaceutical activity, which is beneficial for these PLA-based IBU prodrugs prepared by this convenient one-pot method to be efficiently used in the biochemical and pharmaceutical industry.

Graphical abstract: One-pot preparation of polylactic acid-ibuprofen conjugates and their performance characterization

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Publication details

The article was received on 20 Jul 2017, accepted on 24 Oct 2017 and first published on 24 Oct 2017


Article type: Paper
DOI: 10.1039/C7PY01213F
Citation: Polym. Chem., 2017,8, 7009-7016
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    One-pot preparation of polylactic acid-ibuprofen conjugates and their performance characterization

    S. Luo, Y. Wu, L. Cao, Q. Wang, S. Chen, Z. Hao, L. Jing and Z. Wang, Polym. Chem., 2017, 8, 7009
    DOI: 10.1039/C7PY01213F

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