Jump to main content
Jump to site search


One-pot synthesis of PLA-b-PHEA via sequential ROP and RAFT polymerizations

Author affiliations

Abstract

A block copolymer library of polylactide (PLA) and poly(2-hydroxyethyl acrylate) (PHEA) was prepared via sequential ring opening polymerization (ROP) and reversible addition fragmentation chain transfer (RAFT) polymerization in a one-pot approach. The whole process was conducted at room temperature in THF without employing any protection chemistry or intermediate purification steps. The ROP of L-lactide was performed via in situ calcium alkoxide formation by using 4-cyano-4-[(dodecylsulfanylthiocarbonyl)sulfanyl]pentanol (CDP) and [(THF)2Ca{N(SiMe3)2}2]. The PLA based macro chain transfer agent (CTA) (Mn = 2550 g mol−1, Đ = 1.18) was characterized in-depth by (tandem) mass spectrometry and proved to be suitable to obtain PHEA blocks with Mn values up to 10 000 g mol−1 (Đ ≤ 1.28). Thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC) measurements indicated an increased miscibility between both blocks in bulk as the length of the PHEA unit increases. The amphiphilic block copolymers self-assembled into micellar structures in aqueous media, which were studied by dynamic light scattering (DLS) and cryo-transmission electron microscopy (cryo-TEM).

Graphical abstract: One-pot synthesis of PLA-b-PHEA via sequential ROP and RAFT polymerizations

Back to tab navigation

Supplementary files

Publication details

The article was received on 15 Jul 2017, accepted on 02 Sep 2017 and first published on 04 Sep 2017


Article type: Paper
DOI: 10.1039/C7PY01176H
Citation: Polym. Chem., 2017, Advance Article
  •   Request permissions

    One-pot synthesis of PLA-b-PHEA via sequential ROP and RAFT polymerizations

    I. Yildirim, P. Sungur, A. C. Crecelius-Vitz, T. Yildirim, D. Kalden, S. Hoeppener, M. Westerhausen, C. Weber and U. S. Schubert, Polym. Chem., 2017, Advance Article , DOI: 10.1039/C7PY01176H

Search articles by author

Spotlight

Advertisements