Water-soluble mitochondria-targeting polymeric prodrug micelles for fluorescence monitoring and high intracellular anticancer efficiency†
Abstract
A series of mitochondria-targeting amphipathic prodrugs were developed and subsequently the relationship of different locations of TPP modification and molecular weights of mPEG for selective imaging and therapeutic targeting were tested. The aqueous self-assembled micelles can realize controlled release of free drug, with a faster release at alkaline pH.