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Issue 38, 2017
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Water-soluble mitochondria-targeting polymeric prodrug micelles for fluorescence monitoring and high intracellular anticancer efficiency

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Abstract

A series of mitochondria-targeting amphipathic prodrugs were developed and subsequently the relationship of different locations of TPP modification and molecular weights of mPEG for selective imaging and therapeutic targeting were tested. The aqueous self-assembled micelles can realize controlled release of free drug, with a faster release at alkaline pH.

Graphical abstract: Water-soluble mitochondria-targeting polymeric prodrug micelles for fluorescence monitoring and high intracellular anticancer efficiency

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Publication details

The article was received on 08 Jul 2017, accepted on 08 Aug 2017 and first published on 09 Aug 2017


Article type: Paper
DOI: 10.1039/C7PY01138E
Citation: Polym. Chem., 2017,8, 5982-5987
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    Water-soluble mitochondria-targeting polymeric prodrug micelles for fluorescence monitoring and high intracellular anticancer efficiency

    B. Liu, W. Wu, Y. Liu, C. Jia, X. Yang, J. Li, N. Wang and X. Yu, Polym. Chem., 2017, 8, 5982
    DOI: 10.1039/C7PY01138E

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