Issue 38, 2017

Water-soluble mitochondria-targeting polymeric prodrug micelles for fluorescence monitoring and high intracellular anticancer efficiency

Abstract

A series of mitochondria-targeting amphipathic prodrugs were developed and subsequently the relationship of different locations of TPP modification and molecular weights of mPEG for selective imaging and therapeutic targeting were tested. The aqueous self-assembled micelles can realize controlled release of free drug, with a faster release at alkaline pH.

Graphical abstract: Water-soluble mitochondria-targeting polymeric prodrug micelles for fluorescence monitoring and high intracellular anticancer efficiency

Supplementary files

Article information

Article type
Paper
Submitted
08 Jul 2017
Accepted
08 Aug 2017
First published
09 Aug 2017

Polym. Chem., 2017,8, 5982-5987

Water-soluble mitochondria-targeting polymeric prodrug micelles for fluorescence monitoring and high intracellular anticancer efficiency

B. Liu, W. Wu, Y. Liu, C. Jia, X. Yang, J. Li, N. Wang and X. Yu, Polym. Chem., 2017, 8, 5982 DOI: 10.1039/C7PY01138E

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