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Water-soluble mitochondria-targetingpolymeric prodrug micelles for fluorescence monitoring and high intracellular anticancer efficiency

Abstract

A series of mitochondria-targeting amphipathic prodrugs were developed and subsequently the relationship of different locations of TPP modification and molecular weights¬¬¬ of mPEG for selective imaging and therapeutic targeting were tested. The aqueous self-assembly of micelles can realize controlled release of free drug, while a faster release at alkaline pH.

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Publication details

The article was received on 08 Jul 2017, accepted on 08 Aug 2017 and first published on 09 Aug 2017


Article type: Paper
DOI: 10.1039/C7PY01138E
Citation: Polym. Chem., 2017, Accepted Manuscript
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    Water-soluble mitochondria-targetingpolymeric prodrug micelles for fluorescence monitoring and high intracellular anticancer efficiency

    X. Yu, B. Liu, W. Wu, Y. Liu, C. Jia, X. Yang, J. Li and N. Wang, Polym. Chem., 2017, Accepted Manuscript , DOI: 10.1039/C7PY01138E

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