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Single-chain nanoparticles containing sequence-defined segments: using primary structure control to promote secondary and tertiary structures in synthetic protein mimics

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Abstract

We investigated intra-chain isocyanide-based multicomponent reactions to synthesize single-chain nanoparticles (SCNP) containing sequence-defined segments at each junction point in order to create materials featuring multiple protein-inspired elements. Upon intramolecular cross-linking, nanoparticle formation ensues, affording materials with well-defined structural elements situated in a disordered tertiary structure. The resulting nanostructures were characterized using 1H NMR, DOSY NMR, and size-exclusion chromatography. While covalent cross-linking was the intended and predominant mode of SCNP formation, we found that secondary, noncovalent interactions contributed significantly to nanoparticle folding more akin to natural materials.

Graphical abstract: Single-chain nanoparticles containing sequence-defined segments: using primary structure control to promote secondary and tertiary structures in synthetic protein mimics

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Publication details

The article was received on 07 Jul 2017, accepted on 06 Aug 2017 and first published on 07 Aug 2017


Article type: Paper
DOI: 10.1039/C7PY01133D
Citation: Polym. Chem., 2017, Advance Article
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    Single-chain nanoparticles containing sequence-defined segments: using primary structure control to promote secondary and tertiary structures in synthetic protein mimics

    J. P. Cole, J. J. Lessard, K. J. Rodriguez, A. M. Hanlon, E. K. Reville, J. P. Mancinelli and E. B. Berda, Polym. Chem., 2017, Advance Article , DOI: 10.1039/C7PY01133D

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