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Fabrication of water dispersible and biocompatible AIE-active fluorescent polymeric nanoparticles through a “one-pot” Mannich reaction

Abstract

Fluorescent nanoparticles have been attracting more and more interest from scientists from chemistry, materials, medicals and biology. Among them, the fluorescent nanoparticles with aggregation-induced emission (AIE) characteristic have stand out as the most promising candidates for different applications especially in the biomedical fields. In this work, we reported for the first time that amphiphilic polymers containing hydrophobic AIE dye and hydrophilic poly(ethylene glycol) (PEG) segment can be facilely fabricated based on a Mannich reaction, which could conjugate the phenol hydroxyl-containing AIE dye (PhE-OH), paraformaldehyde and 4-arm poly(ethylene glycol) amine (4-arm PEG-NH2) in one-pot. The obtained PEG-PhE fluorescent polymeric nanoparticles (FPNs) were ascertained by a series of characterization techniques. Moreover, the cell viability and cell uptake behavior of PEG-PhE FPNs were also investigated to evaluate their potential for biomedical applications. The results suggest that the PEG-PhE FPNs show great potential application in the field of biomedical science. More importantly, the strategy used in this work can also be extended for the preparation of many other various AIE-active FPNs with different functional polymers.

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Publication details

The article was received on 28 May 2017, accepted on 03 Jul 2017 and first published on 13 Jul 2017


Article type: Paper
DOI: 10.1039/C7PY00884H
Citation: Polym. Chem., 2017, Accepted Manuscript
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    Fabrication of water dispersible and biocompatible AIE-active fluorescent polymeric nanoparticles through a “one-pot” Mannich reaction

    X. Zhang, G. Zeng, M. Liu, R. Jiang, Q. Huang, L. Huang, Q. Wan, Y. Dai, Y. Wen and Y. Wei, Polym. Chem., 2017, Accepted Manuscript , DOI: 10.1039/C7PY00884H

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