Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance upgrade on Thursday 4th of May 2017 from 8.00am to 9.00am (BST).

During this time our websites will be offline temporarily. If you have any questions please use the feedback button on this page. We apologise for any inconvenience this might cause and thank you for your patience.



Thermo conductive carbon nanotube-framed membranes for skin heat signal-responsive transdermal drug delivery

Author affiliations

Abstract

Smart carbon nanotube (CNT)-framed (SCNF) membranes were prepared by self-assembly of highly thermo conductive CNT molecules hybridized with chitosan (Chit) in a core–shell structure and then by chemical integration of a temperature-responsive copolymer, poly(NIPAAm-co-BVIm) (or pNIBIm), as an additional outer shell. CNT, Chit, and pNIBIm components used in the SCNF membranes function as a thermally conductive CNT-framework, a biocompatible glue to stick the CNT building blocks together, and a temperature-responsive copolymer, respectively. The SCNF membranes with different Chit/CNT ratios and an almost constant pNIBIm concentration (Chit-CNT25-pNIBIm, Chit-CNT50-pNIBIm and Chit-CNT75-pNIBIm) had a three-dimensional interwoven porous nanostructure. Scanning electron microscopy clearly showed the temperature-responsive swelling and deswelling characteristics of the triple core–shell structured CNT-frames. Temperature-dependent bovine serum albumin (BSA)-loading and -release profiles were obtained at 4 °C, 25 °C, 36.5 °C, and 40 °C. The SCNF membranes, especially the Chit-CNT50-pNIBIm hybrid membrane, showed a markedly high loading capacity of 9.7 mg per mg of membrane at 4 °C. The membrane also showed a temperature-dependent BSA-release characteristic (0.92 mg per mg of membrane at 36.5 °C and 3.41 mg per mg of membrane at 40 °C). The SCNF membranes showing highly effective drug-loading/-releasing characteristics could be potentially used as a skin heat signal-responsive patch type transdermal drug delivery (PTDD) system in the medicinal field.

Graphical abstract: Thermo conductive carbon nanotube-framed membranes for skin heat signal-responsive transdermal drug delivery

Back to tab navigation
Please wait while Download options loads

Supplementary files

Publication details

The article was received on 05 Apr 2017, accepted on 19 Apr 2017 and first published on 19 Apr 2017


Article type: Paper
DOI: 10.1039/C7PY00570A
Citation: Polym. Chem., 2017, Advance Article
  •   Request permissions

    Thermo conductive carbon nanotube-framed membranes for skin heat signal-responsive transdermal drug delivery

    J. Kang, H. Kim and U. S. Shin, Polym. Chem., 2017, Advance Article , DOI: 10.1039/C7PY00570A

Search articles by author