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Light-responsive polymer brushes: active topographic cues for cell culture applications

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Abstract

In the call for novel stimuli-responsive biomaterials, azobenzene-containing polymer brushes entail a remarkable potential. In fact, their ability to be patterned at the micro- and nanoscale using interference lithography (IL) might be exploited for the realisation of cell-instructive materials (CIMs). In this work, Disperse Red 1 (DR1)-based photoresponsive polymer brushes were synthesised using a controlled radical polymerisation technique. A sinusoidal pattern was inscribed on the azopolymer brush samples using Lloyd's IL configuration. Interestingly, we found that seeded human umbilical vein endothelial cells (HUVECs) oriented in the pattern direction. Furthermore, using a non-cytotoxic ultrasonication treatment, pattern erasure was achieved. Hence, we envisage the possibility of using these surfaces as reconfigurable cell-instructive biomaterials for tissue engineering applications.

Graphical abstract: Light-responsive polymer brushes: active topographic cues for cell culture applications

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Publication details

The article was received on 17 Mar 2017, accepted on 27 Apr 2017 and first published on 28 Apr 2017


Article type: Paper
DOI: 10.1039/C7PY00462A
Citation: Polym. Chem., 2017, Advance Article
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    Light-responsive polymer brushes: active topographic cues for cell culture applications

    R. H. Kollarigowda, C. Fedele, C. Rianna, A. Calabuig, A. C. Manikas, V. Pagliarulo, P. Ferraro, S. Cavalli and P. A. Netti, Polym. Chem., 2017, Advance Article , DOI: 10.1039/C7PY00462A

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