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Double fluorescence assay via a β-cyclodextrin containing conjugated polymer as a biomimetic material for cocaine sensing

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Abstract

A double fluorescence μ-well assay that exploits a novel conjugated polymer containing cyclodextrin (CD) as the key component is reported. For the construction of the cocaine bioassay, poly(p-phenylene) with CD units in the main-chain and poly(ethylene glycol) side chains (PPP-CD-g-PEG) was first prepared by Suzuki coupling polymerization and coated on each well as a biomimetic material. Although the polyphenylene backbone is responsible for the fluorescence properties without an additional fluorophore, PEG and CD provide water solubility and selective complexation with cocaine, respectively. A cocaine antibody was used as a secondary recognition compound after labelling with quantum dots (QDs). Most notably, we show that the two-color fluorescence nature of the assay facilitates double measurement from the same sample and the described strategy can be adapted to various sensing systems.

Graphical abstract: Double fluorescence assay via a β-cyclodextrin containing conjugated polymer as a biomimetic material for cocaine sensing

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Publication details

The article was received on 11 Mar 2017, accepted on 21 Apr 2017 and first published on 25 Apr 2017


Article type: Paper
DOI: 10.1039/C7PY00420F
Citation: Polym. Chem., 2017, Advance Article
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    Double fluorescence assay via a β-cyclodextrin containing conjugated polymer as a biomimetic material for cocaine sensing

    M. Arslan, T. Yilmaz Sengel, E. Guler, Z. P. Gumus, E. Aldemir, H. Akbulut, H. Coskunol, S. Timur and Y. Yagci, Polym. Chem., 2017, Advance Article , DOI: 10.1039/C7PY00420F

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