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Issue 17, 2017
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Fingerprinting antibiotics with PAE-based fluorescent sensor arrays

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We outline an evolution process for tongue elements composed of poly(p-aryleneethynylene)s (PAE) and detergents, resulting in a chemical tongue (24 elements) that discerns antibiotics. Cross-breeding of this new tongue with tongue elements that consist of simple poly(p-phenyleneethynylene)s (PPE) at different pH-values leads to an enlarged sensor array, composed of 30 elements. This tongue was pruned, employing principal component analysis. We found that a filial tongue featuring three elements from each original array (i.e. a six element tongue) is superior to either of the prior tongues and the composite tongue in the discrimination of structurally different antibiotics. Such a selection process should be general and give an idea how to successfully generate powerful low-selectivity sensor elements and configure them into discriminative chemical tongues.

Graphical abstract: Fingerprinting antibiotics with PAE-based fluorescent sensor arrays

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The article was received on 10 Feb 2017, accepted on 31 Mar 2017 and first published on 31 Mar 2017

Article type: Paper
DOI: 10.1039/C7PY00227K
Citation: Polym. Chem., 2017,8, 2723-2732
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    Fingerprinting antibiotics with PAE-based fluorescent sensor arrays

    J. Han, B. Wang, M. Bender, J. Pfisterer, W. Huang, K. Seehafer, M. Yazdani, V. M. Rotello, C. M. Rotello and U. H. F. Bunz, Polym. Chem., 2017, 8, 2723
    DOI: 10.1039/C7PY00227K

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