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“Click” functionalization of dual stimuli-responsive polymer nanocapsules for drug delivery systems

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Abstract

Surface decoration of nano-carriers is of great importance in targeted drug delivery systems. However, the surface coupling of functional ligands to nano-carriers usually involves sophisticated conjugation chemistry, such as carbodiimide-mediated amide coupling. Herein, “clickable” nanocapsules, containing reactive alkyne groups, were developed for surface functionalization via highly efficient thiol–yne click chemistry and further applied as intelligent drug nano-carriers. Firstly, by employing the facile reflux-precipitation polymerization, the “clickable” nanocapsules with dual thermal and redox responsive properties were readily prepared for further surface functionalization. The “clickable” nanocapsules were subsequently decorated with various functional ligands, including cysteine-folic acid, cysteine-RGD peptide and thiol-functionalized fluorescein isothiocyanate (SH-FITC). Finally, the folate acid-modified nanocapsules (FA-Nanocapsules) were explored as effective drug nano-carriers for doxorubicin (DOX) with triggered release behaviours due to the disulfide linkages and thermo-responsive poly(NIPAAm) components in the nanocapsules. The good growth inhibition of HeLa cells by DOX loaded FA-Nanocapsules indicated that the nanocapsules can be employed as promising drug delivery nano-carriers. The as-prepared dual stimuli-responsive nanocapsules, containing reactive alkyne groups, thus provide a versatile “clickable” platform for surface decoration and functionalization via highly efficient click chemistry.

Graphical abstract: “Click” functionalization of dual stimuli-responsive polymer nanocapsules for drug delivery systems

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Publication details

The article was received on 26 Jan 2017, accepted on 22 Mar 2017 and first published on 27 Mar 2017


Article type: Paper
DOI: 10.1039/C7PY00161D
Citation: Polym. Chem., 2017, Advance Article
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    “Click” functionalization of dual stimuli-responsive polymer nanocapsules for drug delivery systems

    W. J. Yang, T. Zhao, P. Zhou, S. Chen, Y. Gao, L. Liang, X. Wang and L. Wang, Polym. Chem., 2017, Advance Article , DOI: 10.1039/C7PY00161D

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