Investigation on the controlled synthesis and post-modification of poly-[(N-2-hydroxyethyl)-aspartamide]-based polymers

Shixian Lv; Yuchen Wu; Jingqi Dang; Zhaohui Tang; Ziyuan Song; Sheng Ma; Xiao Wang; Xuesi Chen; Jianjun Cheng; Lichen Yin

doi:10.1039/C6PY02230H

Investigation on the controlled synthesis and post-modification of poly-[(N-2-hydroxyethyl)-aspartamide]-based polymers†

Shixian Lv,‡^a Yuchen Wu,‡^a Jingqi Dang,^a Zhaohui Tang,^b Ziyuan Song,^c Sheng Ma,^b Xiao Wang,^a Xuesi Chen,^b Jianjun Cheng*^ac and Lichen Yin

*^a

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* Corresponding authors

^a Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Institute of Functional Nano and Soft Materials (FUNSOM), Soochow University, Suzhou, China
E-mail: lcyin@suda.edu.cn

^b Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, China

^c Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA
E-mail: jianjunc@illinois.edu

Abstract

The production of poly-[(N-2-hydroxyethyl)-aspartamide] (PHEA)-based materials is hampered by the unsatisfactory synthesis and low reactivity in terms of post-modification. Herein, we report the controlled synthesis of PHEA-based polymers, unraveled the hydrogen bonding in PHEA, developed effective approaches to enhance the reactivity of PHEA by improving the temperature, and further demonstrated the desired aqueous solubility as well as the lyophilization stability of PHEA-based amphiphiles. This study will provide insights into the design of useful and functionalized polypeptide-based biomaterials.

Polymer Chemistry

Investigation on the controlled synthesis and post-modification of poly-[(N-2-hydroxyethyl)-aspartamide]-based polymers†

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Investigation on the controlled synthesis and post-modification of poly-[(N-2-hydroxyethyl)-aspartamide]-based polymers

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