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Issue 12, 2017
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Investigation on the controlled synthesis and post-modification of poly-[(N-2-hydroxyethyl)-aspartamide]-based polymers

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Abstract

The production of poly-[(N-2-hydroxyethyl)-aspartamide] (PHEA)-based materials is hampered by the unsatisfactory synthesis and low reactivity in terms of post-modification. Herein, we report the controlled synthesis of PHEA-based polymers, unraveled the hydrogen bonding in PHEA, developed effective approaches to enhance the reactivity of PHEA by improving the temperature, and further demonstrated the desired aqueous solubility as well as the lyophilization stability of PHEA-based amphiphiles. This study will provide insights into the design of useful and functionalized polypeptide-based biomaterials.

Graphical abstract: Investigation on the controlled synthesis and post-modification of poly-[(N-2-hydroxyethyl)-aspartamide]-based polymers

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Publication details

The article was received on 26 Dec 2016, accepted on 06 Feb 2017 and first published on 07 Feb 2017


Article type: Communication
DOI: 10.1039/C6PY02230H
Citation: Polym. Chem., 2017,8, 1872-1877
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    Investigation on the controlled synthesis and post-modification of poly-[(N-2-hydroxyethyl)-aspartamide]-based polymers

    S. Lv, Y. Wu, J. Dang, Z. Tang, Z. Song, S. Ma, X. Wang, X. Chen, J. Cheng and L. Yin, Polym. Chem., 2017, 8, 1872
    DOI: 10.1039/C6PY02230H

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