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Issue 14, 2017
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Biocatalytic atom transfer radical polymerization in a protein cage nanoreactor

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Abstract

Incorporation of the ATRP-catalyzing enzyme horseradish peroxidase (HRP) into the cavities of the group II chaperonin thermosome is demonstrated. The resulting nanoreactor was used to polymerize an acrylate under ARGET ATRP conditions. The confined space within the protein cage results in poly(ethylene glycol) methyl ether acrylate (PEGA) with lower molecular weights (poly(styrene)-apparent Mn = 4400 g mol−1) as well as narrower molecular weight distributions (Đ = 1.08) compared to polymerizations with the free ATRPase (Mn = 43 700 g mol−1 and a Đ of 1.23).

Graphical abstract: Biocatalytic atom transfer radical polymerization in a protein cage nanoreactor

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Publication details

The article was received on 14 Dec 2016, accepted on 10 Mar 2017 and first published on 13 Mar 2017


Article type: Communication
DOI: 10.1039/C6PY02155G
Citation: Polym. Chem., 2017,8, 2133-2136
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    Biocatalytic atom transfer radical polymerization in a protein cage nanoreactor

    K. Renggli, N. Sauter, M. Rother, M. G. Nussbaumer, R. Urbani, T. Pfohl and N. Bruns, Polym. Chem., 2017, 8, 2133
    DOI: 10.1039/C6PY02155G

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