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Photochemical internalization in bladder cancer – development of an orthotopic in vivo model

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Abstract

The possibility of using photochemical internalization (PCI) to enhance the effects of the cytotoxic drug bleomycin is investigated, together with photophysical determination and outlines of a possible treatment for intravesical therapy of bladder cancer. In vitro experiments indicated that the employment of PCI technology using the novel photosensitizer TPCS2a® can enhance the cytotoxic effect of bleomycin in bladder cancer cells. Furthermore, experiments in an orthotopic in vivo bladder cancer model show an effective reduction in both the necrotic area and the bladder weight after TPCS2a based photodynamic therapy (PDT). The tumor selectivity and PDT effects may be sufficient to destroy tumors without damaging the detrusor muscle layer. Our results present a possible new treatment strategy for non-muscle invasive bladder cancer, with the intravesical instillation of the photosensitizer and bleomycin followed by illumination through an optic fiber by using a catheter.

Graphical abstract: Photochemical internalization in bladder cancer – development of an orthotopic in vivo model

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Publication details

The article was received on 16 May 2017, accepted on 01 Sep 2017 and first published on 08 Sep 2017


Article type: Paper
DOI: 10.1039/C7PP00176B
Citation: Photochem. Photobiol. Sci., 2017, Advance Article
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    Photochemical internalization in bladder cancer – development of an orthotopic in vivo model

    O. A. Gederaas, A. Johnsson, K. Berg, R. Manandhar, C. Shrestha, D. Skåre, I. K. Ekroll, A. Høgset and A. Hjelde, Photochem. Photobiol. Sci., 2017, Advance Article , DOI: 10.1039/C7PP00176B

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