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Photochemical internalization in bladder cancer – development of an orthotopic in vivo model

Abstract

The possibility of using photochemical internalization (PCI) to enhance effects of the cytotoxic drug bleomycin is investigated, together with photophysical determinations and outlines of a possible treatment for intravesical therapy of bladder cancer. In vitro experiments indicated that employment of PCI technology using the novel photosensitizer TPCS2a® can enhance the cytotoxic effect of bleomycin in bladder cancer cells. Furthermore, experiments in an orthotopic in vivo bladder cancer model show an effective reduction in both necrotic area and bladder weight after TPCS2a based photodynamic therapy (PDT). The tumor selectivity and PDT effects may be sufficient to destroy tumors without damaging detrusor muscle layer. Our results present a possible new treatment strategy for non-muscle invasive bladder cancer, with intravesical instillation of photosensitizer and bleomycin followed by illumination through an optic fiber by using a catheter.

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Publication details

The article was received on 16 May 2017, accepted on 01 Sep 2017 and first published on 08 Sep 2017


Article type: Paper
DOI: 10.1039/C7PP00176B
Citation: Photochem. Photobiol. Sci., 2017, Accepted Manuscript
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    Photochemical internalization in bladder cancer – development of an orthotopic in vivo model

    O. A. A. Gederaas, A. Johnsson, K. Berg, R. Manandhar, C. Shrestha, D. Skåre, I. Ekroll, A. Hogset and A. Hjelde, Photochem. Photobiol. Sci., 2017, Accepted Manuscript , DOI: 10.1039/C7PP00176B

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