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Antiproliferative activity of 8-methoxypsoralen on DU145 prostate cancer cells under UVA and blue light

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Abstract

The use of photoactivatable 8-methoxypsoralen (8-MOP) as potential focal treatment towards prostate cancer cells is proposed here. Our results, obtained on isolated DNA and DU145 cells, indicate that blue light, besides UVA, is able to activate 8-MOP. When compared to UVA, blue light irradiation led to a modulation of the extent and the types of 8-MOP-DNA damage, specially cross-links, coupled to a still valuable antiproliferative effect. Our data suggest that the proapototic activity of 8-MOP is related not only to DNA damage and reactive oxygen species generation but also to the modulation of cell signalling pathways. In particular, a different activation of p38 and p44/42 mitogen-activated protein kinases was detected depending on the light wavelengths.

Graphical abstract: Antiproliferative activity of 8-methoxypsoralen on DU145 prostate cancer cells under UVA and blue light

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Publication details

The article was received on 29 Mar 2017, accepted on 28 May 2017 and first published on 29 May 2017


Article type: Paper
DOI: 10.1039/C7PP00116A
Citation: Photochem. Photobiol. Sci., 2017, Advance Article
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    Antiproliferative activity of 8-methoxypsoralen on DU145 prostate cancer cells under UVA and blue light

    G. Sturaro, G. Cigolini, L. Menilli, F. Cola, R. Di Liddo, A. Tasso, M. T. Conconi and G. Miolo, Photochem. Photobiol. Sci., 2017, Advance Article , DOI: 10.1039/C7PP00116A

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